Gary R. Bishop, PhD

Professor 
(601) 984-1600

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Current research

The primary mission of my work in the Department of Pharmacology & Toxicology is through the function of the Mass Spectrometry Core Facility (MSCF) which is focused on the broad application of state-of-the-art spectroscopic methods including tandem mass spectrometry and magnetic resonance to the discovery of biomarkers and mechanisms of cardiovascular disease and cancer.  In support of this mission, we maintain advanced tandem mass spectrometric and electron paramagnetic instrumentation as well as support laboratory facilities in the areas of the design, synthesis, modification, and purification of peptide and DNA aptamer-based therapeutics,  mammalian cell culture, and various liquid chromatographic and electrophoretic methods for molecular separations. 

My personal research interests are in pharmacologically active systems where the stability of the drug-receptor complex is attenuated by thermodynamic linkages to solvent interactions, molecular motion (dynamics), conformational changes, and/or aggregation/phase changes.  An increasingly productive area of investigation in our laboratory is the role that biological matrices such as the abundant serum and plasma proteome attenuate on- and off-target interactions in therapeutic monoclonal antibodies (mAbs) and aptamers. Current funded work in the role that expressed micro peptides encoded from long non-coding RNA’s (lncRNA’s)  play in renal cell carcinoma and sarcoma is ongoing.